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I do believe that the heart conditions in Cavalier King Charles Spaniels could be the end result of repeated immunisations by vaccines containing tissue culture contaminants that cause a progressive immune response directed at connective tissue in the heart valves

Finally, TNF- appears to enhance reoxygenation-mediated apoptosis in human coronary artery endothelial cells, with TNF- being one of many pro-inflammatory cytokines released during hypoxia/ischemia as well (see below) (121)